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Activated by the antibiotic rifampicin and many plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to precise ligands is species-particular. Activated by Obviously taking place steroids, for instance pregnenolone and progesterone. Binds to a response factor while in the promoters in the CYP3A4 and ABCB1/MDR1 ge